Reason of State
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Reason of State is a secondary quest that can only be completed during Act III. In order to access it you need to complete all of the Assassin’s quests from Act I. They are A Deadly Plot, An Eye for an Eye and Redania’s Most Wanted. You’ll also need to complete A Matter of Life and Death and Now or Never. During the main quest Blindingly Obvious in Act III you’ll need to bribe Dijkstra rather than persuade him with force.